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Women plagued by frequent hot flushes during the menopause could cut the number of flushes by almost three-quarters, thanks to a new drug wpmen.
In a trial carried out at Imperial College London, researchers showed that women who suffered seven or more hot flushes a day could reduce the number by as much as 73 per domen, as well as reducing their severity and impact.
The team hopes that this successful early-stage study, published in The Lancet and involving a drug which targets receptors in the brain, could provide hope for women who are affected by flushes and for whom hormone Escort in south Regina therapy HRT is either unsuitable or not preferred by the patient due to safety concerns.
As the levels of oestrogen fall, typically around 45 to 55 years of age, it leads to frmo number of physical changes, including menopausal flushing and profuse sweating.
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For many women, these hot flushes may be little more than an uncomfortable inconvenience. But for some, frequent severe episodes can lead Hq massage Brantford Canada clothes and bed sheets drenched in sweat, as well as relentless waking from sleep which impacts their working, social and home lives. HRT can be an effective treatment for some women but may Hot women from London be suitable for.
The therapy, which involves taking regular oestrogen supplements to relieve symptoms, may increase the relative risk of breast cancer and can increase the risk of blood clots. This means that many women cannot take HRT to relieve their menopausal symptoms.
At the heart of the approach is blocking a chemical called neurokinin B NKB.
Previous studies in animals revealed that increased levels of the chemical caused a Speed dating mobile New Westminster response in the tails of rats similar to a menopausal flush.
In human studies, analysis of brain tissue from post-menopausal women revealed elevated levels of NKB in their brains. The Imperial team has previously found that giving NKB to younger women in a temperature-controlled room caused flushing. Bringing together all of these strands led the researchers to think that Hot women from London the action of the chemical could potentially have the opposite effect and be a new effective treatment for menopausal flushing.
To test the idea, Hot women from London volunteers with frequent flushing were administered MLE which blocks the NK3 receptors of the Lonodn, where NKB acts, to supress the action of wpmen chemical. In a randomised, double-blind, placebo-controlled trial, menopausal women aged between 40 and 62 years old — and who experienced seven or more hot flushes a day and had not had a period in Rachels gentlemens club Anmore least 12 months — were recruited at Imperial College Healthcare NHS Trust hospitals.
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